202829 Feb 2012 - Science Daily - Gluten-Free, Casein-Free Diet May Help Some Children With Autism, Research SuggestsGluten-Free, Casein-Free Diet May Help Some Children With Autism, Research Suggests
A gluten-free, casein-free diet may lead to improvements in behavior and physiological symptoms in some children diagnosed with an autism spectrum disorder (ASD), according to researchers at Penn State. The research is the first to use survey data from parents to document the effectiveness of a gluten-free, casein-free diet on children with ASD.02/03/2012
"Research has shown that children with ASD commonly have GI gastrointestinal symptoms," said Christine Pennesi, medical student at Penn State College of Medicine. "Notably, a greater proportion of our study population reported GI and allergy symptoms than what is seen in the general pediatric population. Some experts have suggested that gluten- and casein-derived peptides cause an immune response in children with ASD, and others have proposed that the peptides could trigger GI symptoms and behavioral problems."
See also the news item on Huffington Post UK with comments from The National Autistic Society and the Ambitious About Autism charity here:
3192Jackson et al 2012 - Neurologic and psychiatric manifestations of celiac disease and gluten sensitivityNeurologic and psychiatric manifestations of celiac disease and gluten sensitivity.Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity.
Jackson JR, Eaton WW, Cascella NG, Fasano A, Kelly DL01/03/2012Psychiatr Q. 2012 Mar;83(1):91-102
Celiac Disease (CD) is an immune-mediated disease dependent on gluten (a protein present in wheat, rye or barley) that occurs in about 1% of the population and is generally characterized by gastrointestinal complaints.
More recently the understanding and knowledge of glutensensitivity (GS), has emerged as an illness distinct from celiac disease with an estimated prevalence 6 times that of CD. Gluten sensitive people do not have villous atrophy or antibodies that are present in celiac disease, but rather they can test positive for antibodies to gliadin.
Both CD and GS may present with a variety of neurologic and psychiatric co-morbidities, however, extraintestinal symptoms may be the prime presentation in those with GS. However, glutensensitivity remains undertreated and underrecognized as a contributing factor to psychiatric and neurologicmanifestations.
This review focuses on neurologic and psychiatricmanifestations implicated with glutensensitivity, reviews the emergence of glutensensitivity distinct from celiac disease, and summarizes the potential mechanisms related to this immune reaction.
This review explains why many people who do not have Coeliac disease (the classic form of gluten intolerance) may nonetheless benefit from a gluten-free diet.
The medical establishment has now acknowledged that other forms of sensitivity to gluten do exist - and although their mechanisms are not fully understood, neurological or psychological symptoms appear to be more common in non-coeliac gluten-sensitivity.
celiac, gluten, gluten-sensitivity, dyspraxia, ataxia, psychological, psychiatrichttp://www.ncbi.nlm.nih.gov/pubmed?term=Jackson%20JR%2C%20Eaton%20WW%2C%20Cascella%20NG%2C%20Fasano%20A%2C%20Kelly%20DL.%202012.%20Neurologic%20and%20psychiatric%20manifestations%20of%20celiac%20disease%20and%20gluten%20sensitivity.%20Psychiatric%20Quarterly.%20Mar%3B83(1)%3A91-102.View this and related abstracts via PubMed here. Full free text is available online.
2032Tan et al 2012 - Red blood cell omega-3 fatty acid levels and markers of accelerated brain agingRed blood cell omega-3 fatty acid levels and markers of accelerated brain agingRed blood cell omega-3 fatty acid levels and markers of accelerated brain agingTan Z S, Harris W S, Beiser A S, Au R, Himali J J, Debette S, Pikula A, DeCarli C, Wolf P A, Vasan R S, Robins S J, Seshadri S28/02/2012doi: 10.1212/WNL.0b013e318249f6a9 Neurology February 28, 2012 vol. 78 no. 9 658-664
Objective: Higher dietary intake and circulating levels of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have been related to a reduced risk for dementia, but the pathways underlying this association remain unclear. We examined the cross-sectional relation of red blood cell (RBC) fatty acid levels to subclinical imaging and cognitive markers of dementia risk in a middle-aged to elderly community-based cohort.
Methods: We related RBC DHA and EPA levels in dementia-free Framingham Study participants (n = 1,575; 854 women, age 67 ± 9 years) to performance on cognitive tests and to volumetric brain MRI, with serial adjustments for age, sex, and education (model A, primary model), additionally for APOE ?4 and plasma homocysteine (model B), and also for physical activity and body mass index (model C), or for traditional vascular risk factors (model D).
Results: Participants with RBC DHA levels in the lowest quartile (Q1) when compared to others (Q2–4) had lower total brain and greater white matter hyperintensity volumes (for model A: β ± SE = −0.49 ± 0.19; p = 0.009, and 0.12 ± 0.06; p = 0.049, respectively) with persistence of the association with total brain volume in multivariable analyses. Participants with lower DHA and ω-3 index (RBC DHA+EPA) levels (Q1 vs Q2–4) also had lower scores on tests of visual memory (β ± SE = −0.47 ± 0.18; p = 0.008), executive function (β ± SE = −0.07 ± 0.03; p = 0.004), and abstract thinking (β ± SE = −0.52 ± 0.18; p = 0.004) in model A, the results remaining significant in all models.
Conclusion: Lower RBC DHA levels are associated with smaller brain volumes and a “vascular” pattern of cognitive impairment even in persons free of clinical dementia.
diet and nutrition, aging, memory, dementiahttp://www.neurology.org/content/78/9/658.abstract?sid=53ea67a4-7195-46a7-b502-15c94724cd0cView this abstract in the Journal of Neurology here
202527 Feb 2012 - HealthDay News - Omega-3 Fatty Acids May Protect the Aging BrainOmega-3 Fatty Acids May Protect the Aging Brain; diet, nutrition, memoryThose who consumed the most did better on tests of mental functioning, study says27/02/2012
Middle-aged and elderly adults who regularly eat foods rich in omega-3 fatty acids may slow the mental decline that leads to dementia, according to a new study.
Researchers found that people with the highest blood levels of these essential fatty acids -- found in fish such as salmon and tuna -- were more likely to perform well on tests of mental functioning and to experience less age-related brain shrinkage.
"We feel fatty acid consumption exerts a beneficial effect on brain aging by promoting vascular health," said study lead author Dr. Zaldy Tan, an associate professor in the Easton Center for Alzheimer's Disease Research and the division of geriatrics at the University of California, Los Angeles. This might include reducing blood pressure and inflammation, he added.
203021 Feb 2012 - Nutraingredients - 'Mild' dehydration may modify moods, say scientistsdehydration, EFSA, water, mood, energyEven mild dehydration can alter a person's mood, energy level, and ability to think clearly, leaving them 'cranky' and tired, say researchers.21/02/2012
According to the study, published in the British Journal of Nutrition, even before we become thirsty, mild hydration could be enough to alter our mood and energy levels.
The study, led by Professor Lawrence Armstrong of the University of Connecticut, USA, revealed that the adverse effects from mild hydration, which is defined as 1.5% loss in normal water volume, were the same whether people were sitting at rest or active.
Professor Armstrong said the results assert the importance of staying properly hydrated at all times, and not just during exercise, extreme heat or exertion.
"Our thirst sensation doesn't really appear until we are 1 or 2 percent dehydrated. By then dehydration is already setting in and starting to impact how our mind and body perform".
"Dehydration affects all people, and staying properly hydrated is just as important for those who work all day at a computer as it is for marathon runners, who can lose up to 8 percent of their body weight as water when they compete", he affirmed.
Dr Harris Lieberman, a co-author of the research explained "Even mild hydration that can occur during the course of our ordinary daily activities can degrade how we are feeling - especially for women, who appear to be more susceptible to the adverse effects of low levels of dehydration than men".
http://www.nutraingredients.com/Research/Mild-dehydration-may-modify-mood-say-scientists?nocountRead the full news item on Nutraingredients hereMP900422274.jpgWoman drinking glass of water
202416 Feb 2012 - BBC News - Children 'watch same level' of junk food ads despite tv rulesjunk food advertisingChildren are still exposed to the same level of junk food advertising despite tighter regulations, research suggests.16/02/2012
The UK regulations ban the advertising of foods high in fat, salt or sugar during children's programming.
Newcastle University academics said 6.1% of adverts seen by children were about junk food before the ban - the figure was 7% after the ban.
They said young people do not just watch children's programmes, to which the rules apply.
http://www.bbc.co.uk/news/health-17041347Read the full news item on the BBC News website here7573347.jpgHot dog
2121Barker 2012 - Sir Richard Doll Lecture. Developmental origins of chronic diseaseSir Richard Doll Lecture. Developmental origins of chronic diseaseSir Richard Doll Lecture. Developmental origins of chronic diseaseBarker DJ10/02/2012Public Health. 126(3):185-9. Epub 2012 Feb 10.
Coronary heart disease, type 2 diabetes, breast cancer and many other chronic diseases are unnecessary. Their occurrence is not mandated by genes passed down to us through thousands of years of evolution.
Chronic diseases are not the inevitable lot of humankind. They are the result of the changing pattern of human development. We could readily prevent them, had we the will to do so.
Prevention of chronic disease, and an increase in healthy ageing require improvement in the nutrition of girls and young women.
Many babies in the womb in the Western world today are receiving unbalanced and inadequate diets. Many babies in the developing world are malnourished because their mothers are chronically malnourished.
Protecting the nutrition and health of girls and young women should be the cornerstone of public health. Not only will this prevent chronic disease, but it will produce new generations who have better health and well-being through their lives.
It is difficult to overstate the importance of the findings that Professor Barker has so elegantly summarised in this lecture.
As he emphasises, most of the chronic diseases that increasingly afflict people in both developed and developing countries could actually be prevented if women of childbearing age were adequately nourished.
Robust evidence shows that 'nutritional programming' effects (reflecting the mother's diet and nutritional status) permanently shape a child's lifetime health risks. Much of this programming occurs before that child is even born, although the critical time window extends to around the first 1000 days from conception.
The lifelong risks from early malnutrition extend to mental as well as physical health disorders.
The full text of this article is freely available online here
Nutritional programming, review, free full texthttp://www.ncbi.nlm.nih.gov/pubmed/22325676View this and related abstracts via PubMed here. Free full text of this article is available online.
2043Sapone et al 2012 - Spectrum of gluten-related disorders: consensus on new nomenclature and classificationSpectrum of gluten-related disorders: consensus on new nomenclature and classificationSpectrum of gluten-related disorders: consensus on new nomenclature and classificationSapone A, Bai JC, Ciacci C, Dolinsek J, Green PH, Hadjivassiliou M, Kaukinen K, Rostami K, Sanders DS, Schumann M, Ullrich R, Villalta D, Volta U, Catassi C, Fasano A07/02/2012BMC Med. 2012 Feb 7;10(1):13.
A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity into the popular spotlight worldwide. Now we are observing another interesting phenomenon that is generating great confusion among health care professionals. The number of individuals embracing a gluten-free diet (GFD) appears much higher than the projected number of celiac disease patients, fueling a global market of gluten-free products approaching $2.5 billion (US) in global sales in 2010. This trend is supported by the notion that, along with celiac disease, other conditions related to the ingestion of gluten have emerged as health care concerns. This review will summarize our current knowledge about the three main forms of gluten reactions: allergic (wheat allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated (gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new nomenclature and classifications.
celiac, gluten, allergyhttp://www.ncbi.nlm.nih.gov/pubmed/22313950View this and related abstracts via PubMed here. Free full text is available online
2023Quigley et al 2012 - Breastfeeding is Associated with Improved Child Cognitive Development: A Population-Based Cohort StudyBreastfeeding is Associated with Improved Child Cognitive Development: A Population-Based Cohort StudyBreastfeeding is Associated with Improved Child Cognitive Development: A Population-Based Cohort StudyMaria A. Quigley, Christine Hockley, Claire Carson, Yvonne Kelly, Mary J. Renfrew, Amanda Sacker06/02/2012The Journal of Paediatrics160, Issue 125-32
OBJECTIVE: To assess the association between breastfeeding and child cognitive development in term and preterm children.
STUDY DESIGN: We analyzed data on white singleton children from the United Kingdom Millennium Cohort Study. Children were grouped according to breastfeeding duration. Results were stratified by gestational age at birth: 37 to 42 weeks (term, n = 11,101), and 28 to 36 weeks (preterm, n = 778). British Ability Scales tests were administered at age 5 years (naming vocabulary, pattern construction, and picture similarities subscales).
RESULTS: The mean scores for all subscales increased with breastfeeding duration. After adjusting for confounders, there was a significant difference in mean score between children who were breastfed and children who were never breastfed: in term children, a two-point increase in score for picture similarities (when breastfed ≥ 4 months) and naming vocabulary (when breastfed ≥ 6 months); in preterm children, a 4-point increase for naming vocabulary (when breastfed ≥ 4 months) and picture similarities (when breastfed ≥ 2 months) and a 6-point increase for pattern construction (when breastfed ≥ 2 months). These differences suggest that breastfed children will be 1 to 6 months ahead of children who were never breastfed.
CONCLUSIONS: In white, singleton children in the United Kingdom, breastfeeding is associated with improved cognitive development, particularly in children born preterm.
breastfeeding; cognitive developmenthttp://www.ncbi.nlm.nih.gov/pubmed/21839469View this and related abstracts via Pubmed here
2038Miller et al 2012 - PubMed - Berry Fruit Enhances Beneficial Signaling In The BrainBerry Fruit Enhances Beneficial Signaling In The BrainBerry Fruit Enhances Beneficial Signalling In The BrainMiller MG, Shukitt-Hale B03/02/2012J Agric Food Chem. 2012 Feb 3
Increased lifespans have led to population aging and brought attention to healthcare concerns associated with old age. A growing body of preclinical and clinical research has identified neurological benefits associated with the consumption of berry fruits. In addition to their now well-known antioxidant effects, dietary supplementation with berry fruits also has direct effects on the brain. Intake of these fruits may help to prevent age-related neurodegeneration and resulting changes in cognitive and motor function. In cell and animal models, berry fruits mediate signaling pathways involved in inflammation and cell survival in addition to enhancing neuroplasticity, neurotransmission, and calcium buffering, all of which lead to attenuation of age- and pathology-related deficits in behavior. Recent clinical trials have extended these antioxidant, anti-inflammatory, and cognition-sparing effects to humans. This paper reviews recent evidence for the beneficialsignaling effects of berry fruits on the brain and behavior.
berries; brain; aging; signaling; antioxidants; anti-inflammatory; behaviour; behaviorhttp://www.ncbi.nlm.nih.gov/pubmed/22264107View this and related abstracts via PubMed here
20362 Feb 2012 - BBC News - Sugar tax needed, say US expertsSugarSugar is as damaging and addictive as alcohol or tobacco and should be regulated, claim US health experts.02/02/2012by Helen Briggs
According to a University of California team, new policies such as taxes are needed to control soaring consumption of sugar and sweeteners.
Prof Robert Lustig argues in the journal Nature for major shifts in public policy.
Industry body the Food and Drink Federation said "demonising" food was unhelpful.
Several countries are imposing taxes on unhealthy food; Denmark and Hungary have a tax on saturated fat, while France has approved a tax on soft drinks.
Now, researchers in the US are proposing similar policies for added sugar and sweeteners, amid concern about the amount of sugar in the diet.
The consumption of sugar has tripled worldwide over the past 50 years, with links to obesity, high blood pressure and diabetes.
In a comment in the journal Nature, Prof Lustig, a leading child obesity expert, says governments need to consider major shifts in policy, such as taxes, limiting sales of sweet food and drinks during school hours, or even stopping children from buying them below a certain age.
The professor of paediatrics at the University of California, San Francisco, told the BBC: "It (sugar) meets all the criteria for societal intervention that alcohol and tobacco meet."
The researchers acknowledge that they face "an uphill political battle against a powerful sugar lobby".
But they write in Nature, that "with enough clamour for change, tectonic shifts in policy become possible".
"Take, for instance bans on smoking in public places and the use of designated drivers, not to mention airbags in cars and condom dispensers in public bathrooms.
"These simple measures - which have all been on the battleground of American politics - are now taken for granted as essential tools for our public health and well-being. It's time to turn our attention to sugar."
Robert H Lustig MD UCSF Professor of Paediatrics in the Division of Endocrinology, gave a lecture called 'Sugar - The Bitter Truth' on 26 May 2009. The following July, it was then posted on YouTube and to date has been viewed well over a million times. In his lecture, Professor Lustig explores the damage caused by sugary foods. He argues that too much fructose and not enough fibre appear to be cornerstones of the obesity epidemic through their effects on insulin and other hormones. (For a peer-reviewed account of Lustig's theory, see his 2006 review in Nature Endocrinology)
The New York Times published a review of this lecture on 13 April 2011 which you can view here:
19882 February 2012 - The Dyscovery Centre's 15th Anniversary - Newport, WalesThe Dyscovery Centre's 15th Anniversary, University of Wales, NewportThe Dyscovery Centre02/02/201202/02/2012
This day of celebration will begin with presentations about the knowledge around Developmental Co-ordination Disorder (DCD/Dyspraxia) and related specific learning difficulties, and how this has evolved in the past 15 years. The wide range of afternoon workshops will provide opportunities for discussion and participation.
Guest speakers will include:
Professor David Sugden (Leeds) Dr Paul Hutchins (Australia) Professor Anita Thapar (Cardiff) Dr Anna Barnett (Oxford Brookes) Professor Barry Carpenter OBE Angela Webb (National Handwriting Association) Dr Ian Smythe
Other emiment speakers will be joining the centre on the day.
Topics covered will include:
DCD consensus statement implementation
Key changes in DCD problem solving approaches
Practical support strategies for children and adults
Supporting adults with DCD/Spld into employment, use of IT, transition and more
Fee for the day: £30 per person (non-refundable) including a light lunch and refreshments.
To book, contact The Dyscovery Centre, but hurry - places are very limited!
9.30am to 4.00 pmNewport, WalesThe Dyscovery Centre, Felthorpe House, University of Wales, Newport, Caerleon Campus, Lodge Road, Caerleon, Newport NP18 3QTdyscoverycentre@newport.ac.uk01633 432330http://www.newport.ac.uk/research/researchcentres/Centres/Dyscovery%20Centre/Pages/default.aspxMore about The Dyscovery Centre hereDyscovery 15th Anniversary 2nd Feb 2012 flyer.pdfDownload flyer hereDyscLogo.jpgDysc Logo
20221 Feb 2012 - MNT - Mothers Who Eat Fish While Pregnant Produce Offspring With Better Cognitive DevelopmentMothers who eat fish while pregnantDoes eating fish during pregnancy improve a child's intelligence? According to a recent study published in the American Journal of Clinical Nutrition the answer is yes.01/02/2012by Petra Rattue - Medical News Today
The study revealed that infants of mothers who consumed more fish during pregnancy achieved higher scores in verbal intelligence and fine motor skill testing, as well as having a higher pro-social behavior. The study is part of the NUTRIMENTHE project "Effect of diet on offspring's cognitive development", which focuses on the effects of genetic variants and maternal fish intake on the children's intellectual capacity.
http://www.medicalnewstoday.com/articles/241045.phpRead the full news item in Medical News Today here
2068Gu et al 2012 - Nutrient intake and plasma ß-amyloidNutrient intake and plasma ß-amyloidGu et al 2012 - Nutrient intake and plasma ß-amyloidGu Y, Schupf N, Cosentino S A, Luchsinger J A, Scarmeas N31/01/2012Neurology WNL.0b013e318258f7c2
Objective: The widely reported associations between various nutrients and cognition may occur through many biologic pathways including those of β-amyloid (Aβ). However, little is known about the possible associations of dietary factors with plasma Aβ40 or Aβ42. The aim of the current study was to evaluate the association between nutrient intake and plasma Aβ levels.
Methods: In this cross-sectional study, plasma Aβ40 and Aβ42 and dietary data were obtained from 1,219 cognitively healthy elderly (age >65 years), who were participants in a community-based multiethnic cohort. Information on dietary intake was obtained 1.2 years, on average, before Aβ assay. The associations of plasma Aβ40 and Aβ42 levels and dietary intake of 10 nutrients were examined using linear regression models, adjusted for age, gender, ethnicity, education, caloric intake, apolipoprotein E genotype, and recruitment wave. Nutrients examined included saturated fatty acid, monounsaturated fatty acid, ω-3 polyunsaturated fatty acid (PUFA), ω-6 PUFA, vitamin E, vitamin C, β-carotene, vitamin B12, folate, and vitamin D.
Results: In unadjusted models that simultaneously included all nutrients, higher intake of ω-3 PUFA was associated with lower levels of Aβ40 (β = −24.7, p < 0.001) and lower levels of Aβ42 (β = −12.3, p < 0.001). In adjusted models, ω-3 PUFA remained a strong predictor of Aβ42 (β = −7.31, p = 0.02), whereas its association with Aβ40 was attenuated (β = −11.96, p = 0.06). Other nutrients were not associated with plasma Aβ levels.
Conclusions: Our data suggest that higher dietary intake of ω-3 PUFA is associated with lower plasma levels of Aβ42, a profile linked with reduced risk of incident AD and slower cognitive decline in our cohort.
http://www.neurology.org/content/early/2012/05/02/WNL.0b013e318258f7c2.abstract?sid=3c4872c8-fb70-4963-859c-25abcf075177View this and related abstracts via Neurology here
2021Palmer et al 2012 - Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trialEffect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trialEffect of n-3 long chain polyunsaturated fatty acid
supplementation in pregnancy on infants' allergies in
first year of life: randomised controlled trialPalmer D J, Sullivan T, Gold M S, Prescott S L, Heddle R, Gibson R A, Makrides M31/01/2012BMJ 2012;344:e184 doi: 10.1136/bmj.e184
Objective To determine whether dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation of pregnant women with a fetus at high risk of allergic disease reduces immunoglobulin E associated eczema or food allergy at 1 year of age.
Design Follow-up of infants at high hereditary risk of allergic disease in the Docosahexaenoic Acid to Optimise Mother Infant Outcome (DOMInO) randomised controlled trial.
Setting Adelaide, South Australia.
Participants 706 infants at high hereditary risk of developing allergic disease whose mothers were participating in the DOMInO trial.
Interventions The intervention group (n=368) was randomly allocated to receive fish oil capsules (providing 900 mg of n-3 LCPUFA daily) from 21 weeks’ gestation until birth; the control group (n=338) received matched vegetable oil capsules without n-3 LCPUFA.
Main outcome measure Immunoglobulin E associated allergic disease (eczema or food allergy with sensitisation) at 1 year of age.
Results No differences were seen in the overall percentage of infants with immunoglobulin E associated allergic disease between the n-3 LCPUFA and control groups (32/368 (9%) v 43/338 (13%); unadjusted relative risk 0.68, 95% confidence interval 0.43 to 1.05, P=0.08; adjusted relative risk 0.70, 0.45 to 1.09, P=0.12), although the percentage of infants diagnosed as having atopic eczema (that is, eczema with associated sensitisation) was lower in the n-3 LCPUFA group (26/368 (7%) v 39/338 (12%); unadjusted relative risk 0.61, 0.38 to 0.98, P=0.04; adjusted relative risk 0.64, 0.40 to 1.02, P=0.06). Fewer infants were sensitised to egg in the n-3 LCPUFA group (34/368 (9%) v 52/338 (15%); unadjusted relative risk 0.61, 0.40 to 0.91, P=0.02; adjusted relative risk 0.62, 0.41 to 0.93, P=0.02), but no difference between groups in immunoglobulin E associated food allergy was seen.
Conclusion n-3 LCPUFA supplementation in pregnancy did not reduce the overall incidence of immunoglobulin E associated allergies in the first year of life, although atopic eczema and egg sensitisation were lower. Longer term follow-up is needed to determine if supplementation has an effect on respiratory allergic diseases and aeroallergen sensitisation in childhood.
http://www.bmj.com/content/344/bmj.e184View this paper on the BMJ website here - open access
2044Pietzak 2012 - Celiac disease, wheat allergy, and gluten sensitivity: when gluten free is not a fadCeliac disease, wheat allergy, and gluten sensitivity: when gluten free is not a fadCeliac disease, wheat allergy, and gluten sensitivity: when gluten free is not a fadPietzak M31/01/2012JPEN J Parenter Enteral Nutr. 2012 Jan;36(1 Suppl):68S-75S.
As the gluten-free diet (GFD) gains in popularity with the general public, health practitioners are beginning to question its real health benefits.
For those patients with celiac disease (CD), the GFD is considered medical nutrition therapy, as well as the only proven treatment that results in improvements in symptomatology and small bowel histology.
Those with wheat allergy also benefit from the GFD, although these patients often do not need to restrict rye, barley, and oats from their diet.
Gluten sensitivity is a controversial subject, where patients who have neither CD nor wheat allergy have varying degrees of symptomatic improvement on the GFD. Conditions in this category include dermatitis herpetiformis (DH), irritable bowel syndrome (IBS), and neurologic diseases such as gluten-sensitive ataxia and autism.
It is important for patients and healthcare practitioners to understand the differences between these conditions, even though they may all respond to a GFD.
Patients with CD can experience comorbid nutrition deficiencies and are at higher risk for the development of cancers and other autoimmune conditions. Those with wheat allergy and gluten sensitivity are thought not to be at higher risk for these complications.
Defining the symptoms and biochemical markers for gluten-sensitive conditions is an important area for future investigations, and high-quality, large-scale randomized trials are needed to prove the true benefits of the GFD in this evolving field.
201222 Jan 2012 - The Daily Mail YOU Magazine - ADHD and a Dietary Alternative to RitalinADHD and ritalin22/01/2012by Sarah Stacey
Q: My young son has ADHD and the doctor wants to put him on Ritalin. I have some concerns about this drug. Are there any alternatives, preferably natural ones?
A: Attention deficit hyperactivity disorder (ADHD) involves serious and persistent difficulties with attention and concentration and/or hyperactive and impulsive behaviour. It is said to affect at least five per cent of children in the UK, but the diagnosis is controversial, says Dr Alex Richardson of the Centre for Evidence-Based Intervention at Oxford University. ‘There are no objective tests, and distinctions from normal behaviour are not clear-cut. Also many different things can cause or exacerbate symptoms. You should make sure your son’s problems are not primarily caused by sleep difficulties, lack of exercise, or worries about school or home.’
Purchase your copy of They Are What You Feed Themhere, or receive this book free when you become an Associate Member of FAB Research.
http://www.dailymail.co.uk/home/you/article-2088952/Health-Attention-grabbing-alternatives.htmlRead the rest of what Dr Richardson has to say on The Daily Mail website hereTAWYFT.jpgtawyft
2058Cunnane et al 2012 - Plasma and Brain Fatty Acid Profiles in Mild Cognitive Impairment and Alzheimer's DiseasePlasma and Brain Fatty Acid Profiles in Mild Cognitive Impairment and Alzheimer's DiseasePlasma and Brain Fatty Acid Profiles in Mild Cognitive Impairment and Alzheimer's DiseaseCunnane SC, Schneider JA, Tangney C, Tremblay-Mercier J, Fortier M, Bennett DA, Morris MC20/01/2012J Alzheimers Dis. 2012 Jan 20
Alzheimer's disease (AD) is generally associated with lower omega-3 fatty acid intake from fish but despite numerous studies, it is still unclear whether there are differences in omega-3 fatty acids in plasma or brain. In matched plasma and brain samples provided by the Memory and Aging Project, fatty acidprofiles were quantified in several plasma lipid classes and in three brain cortical regions. Fatty acid data were expressed as % composition and as concentrations (mg/dL for plasma or mg/g for brain). Differences in plasmafatty acidprofiles between AD, mild cognitive impairment (MCI), and those with no cognitive impairment (NCI) were most apparent in the plasma free fatty acids (lower oleic acid isomers and omega-6 fatty acids in AD) and phospholipids (lower omega-3 fatty acids in AD). In brain, % DHA was lower only in phosphatidylserine of mid-frontal cortex and superior temporal cortex in AD compared to NCI (-14% and -12%, respectively; both p < 0.05). The only significant correlation between plasma and brainfatty acids was between % DHA in plasma total lipids and % DHA in phosphatidylethanolamine of the angular gyrus, but only in the NCI group (+0.77, p < 0.05). We conclude that AD is associated with altered plasma status of both DHA and other fatty acids unrelated to DHA, and that the lipid class-dependent nature of these differences reflects a combination of differences in intake and metabolism.
http://www.ncbi.nlm.nih.gov/pubmed/22269159View this and related abstracts via PubMed here
200111 Jan 2012 - MedicalXpress - Omega-3 fatty acids could prevent and treat nerve damage, research suggestsOmega-3 and nerve damageResearch from Queen Mary, University of London suggests that omega-3 fatty acids, which are found in fish oil, have the potential to protect nerves from injury and help them to regenerate.14/01/2012
When nerves are damaged because of an accident or injury, patients experience pain, weakness and muscle paralysis which can leave them disabled, and recovery rates are poor.
The new study, published this week in the Journal of Neuroscience, suggests that omega-3 fatty acids could play a significant role in speeding recovery from nerve injury.
For further information on the study reported in this news article, see
20059 Jan 2012 - MedPage Today - Pediatric Study: 'Healthy' Diet Best for ADHD KidsDiet and ADHDFast foods, sodas, and ice cream may be American kids' favorite menu items, but they're also probably the worst for those with attention deficit-hyperactivity disorder (ADHD), a new literature review suggests.09/01/2012By John Gever, Senior Editor, MedPage Today
According to two researchers from Children's Memorial Hospital in Chicago, a relatively simple diet low in fats and high in whole grains, fruits, and vegetables is one of the best alternatives to drug therapy for ADHD. Omega-3 and omega-6 fatty acid supplements have also been shown to help in some controlled studies, they noted.
Writing online in Pediatrics, J. Gordon Millichap, MD, and Michelle M. Yee, CPNP, reviewed nearly 70 publications on diet-based interventions in ADHD, emphasizing recent research and controlled trials.
They noted that diet is one established contributor to ADHD that parents can modify.
It is good to see recognition of the increasing evidence that diet really can play a role in managing ADHD-type symptoms.
Furthermore, this important new review does a very good job of distinguishing between dietary approaches that are likely to help only small subgroups of ADHD children (and which usually require professional assistance as well as considerable effort), and those which are suitable for anyone wanting to reduce attentional problems, hyperactivity or impulsivity.
For more details, please use the link below to read the full article on MedPage today. See also:
To read pdf documents on this site you may need to download
Adobe Acrobat Reader. Get it here.
Website Glossary If you hover your mouse over words that appear underlined
with a blue, dashed line, a definition of that word will appear as a 'tooltip'. You may find further information about the term in our
Food and Behaviour Research is a registered charity (No SC034604) and a company limited by guarantee (Co No SC 253448).
FAB Research | The Green House | Beechwood Business Park | Inverness | Scotland
| IV2 3BL | Telephone: 01463 667318 Website by Calligrafix
Medical opinion and guidance should always be sought for any symptoms that might
possibly reflect a known or suspected disease, disorder or medical condition. Information
provided on this website (or by FAB Research via any other means) does not in any
way constitute advice on the treatment of any medical condition formally diagnosed