Food and Behaviour Research

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13 April 2016 - Foodnavigator - Switching from saturated fat to vegetable oil cuts cholesterol but increases heart attack risk: Review

Niamh Michail


For more details of this research see:
This new study shows that long-standing public health advice to reduce saturated fats, and instead to consume more 'polyunsaturated fatty acids' (PUFA) from vegetable oils rich in omega-6 fats does NOT promote heart health.

In fact, it appears to do quite the opposite - leading to MORE cardiovascular events - as shown by newly analysed data from the largest,most detailed randomised controlled trial ever conducted to investigate this issue. This trial was conducted 50 years ago, but its results were never fully published then (for reasons that remain unclear).

Several years ago, the same researchers examined the clinical trial evidence for the 'diet-heart hypothesis' by comparing for the first time trials using vegetable oils with omega-6 only with those using mixed omega-6 /omega-3.  Again, vegetable oils rich in omega-6 only were found to be associated with more heart disease, not less. See:

Switching from saturated fat to vegetable oils that are rich in linoleic acid reduces cholesterol but actually increases the incidence of heart attacks and heart disease, according to a recent review of a data collected nearly 50 years ago.

Replacing saturated, animal-derived fats such as butter, lard and cheese with vegetable oils that are rich in linoleic acid – such as those derived from corn, sunflower, safflower, cottonseed or soybean – has long been thought to decrease cholesterol and, as a result, coronary heart disease and overall mortality rates.

But a review of the Minnesota Coronary Experiment (MCE) - a study that was originally conducted almost 50 years ago has cast this belief - which has formed a key component of dietary advice for years - into doubt.

Daisy Zamora, a researcher at the University of North Carolina and co-author of the review that was published yesterday in the British Medical Journal said: "Altogether, this research leads us to conclude that incomplete publication of important data has contributed to the overestimation of benefits - and the underestimation of potential risks - of replacing saturated fat with vegetable oils rich in linoleic acid."

The Minnesota Coronary Experiment

Conducted between 1968 and 1973, the MCE was the largest and, according to the review's authors, “most rigorously executed” dietary trial that looked at the effects of replacing saturated with unsaturated fats  in 9,423 patients in six mental hospitals and one state-run nursing home in Minnesota.

The results were originally published in 1989 with the researchers concluding that switching from butter to corn oil lowered cholesterol levels but made no difference to rates of heart attacks, death from heart attacks or overall mortality rate.

But, for unknown reasons, the original researchers did not publish several critical analyses. Zamora and the team of researchers therefore put the recovered data into context and conducted a systematic review and meta-analysis of the trials.

They found that the corn oil group had almost twice as many heart attacks as the control: 41% of participants in the vegetable oil group had at least one myocardial infarct, compared with only 22% of participants in the control group, nor did participants in the intervention group have less coronary atherosclerosis or aortic atherosclerosis. The risk of death was also greater among older participants, increasing 35% with every 30 mg/dL decrease in serum cholesterol, even when adjusted for changed in body weight and blood pressure, as markers of frailty.

“The partial recovery of 149 heart and aorta autopsy files provides an intriguing clue that the intervention might have had unfavourable effects. As 146 heart and aorta files and the data on the full cohort of 295 autopsied brains remain missing, however, one cannot draw conclusions from these provisional findings,” write the authors. Given the unlikelihood of a study of this size being replicated again, they say it is essential that the missing autopsy files are recovered and analysed.

The consequences of this incomplete knowledge may have skewed public health policy.

"Whatever the explanation for key MCE data not being published, there is growing recognition that incomplete publication of negative or inconclusive results can contribute to skewed research priorities and public health initiatives," they write.

The authors had previously found similar results in a previous study, the Sydney Diet Heart Study.

Oxidation may be behind the “seemingly paradoxical results” of both studies, they write. “Consumption of vegetable oils rich in linoleic acid produces a wide range of biochemical consequences, including qualitative changes in lipoprotein particle oxidation that could plausibly increase risk of coronary heart disease. Hence the clinical effects of replacing saturated fat with vegetable oils could reflect the net impact of decreasing low density lipoprotein while increasing its susceptibility to oxidation.”