Food and Behaviour Research

Donate Log In

Children’s Food and Mood: What Works, What Matters - BOOK HERE

Antidepressants Plus Nutritional Supplements, Like Omega 3 And Vitamin D, May Treat Depression More Effectively

Lecia Bushak


Antidepressant medications may be more effective for many people if these are combined with dietary supplementation of some nutrients, including the long-chain omega-3 fats found in fish oils, methylfolate (a special form of vitamin B9) and Vitamin D.

These findings come from a systematic review of controlled clinical trials - regarded as the highest level of scientific evidence for assessing cause and effect relationships. They are also consistent with substantial evidence from population and case-control studies showing that these and other nutrient deficiencies are more common in people diagnosed with clinical-level depression. 

See the associated research here:

See also the accompanying news article and FAB comment:

And for practical information on food and diet in relation to mental health, as well as links to more research in this area, see the highly accessible recent article by the lead author, Jerome Sarris:

26 April 2016 - Medical Daily

Researchers have found that taking some nutritional supplements — such as omega-3 fish oil and Vitamin D — could increase the efficacy of antidepressants among people who suffer from clinical depression.

Taking nutritional supplements in addition to antidepressants may help reduce clinical depression, according to a new study out of the University of Melbourne and Harvard.

Omega-3 fish oils, S-adenosylmethionine (SAMe), methylfolate, and Vitamin D were shown to be effective in boosting the positive effects of the antidepressants.

The researchers reviewed several international studies to conclude that nutritional supplements could improve outcomes for people on antidepressants. Omega-3 fish oil, in particular, proved to be the most effective. In the past, researchers have linked Omega-3 fatty acids, which comprise the fish oil and are found in fatty fish like salmon, to improved mood and depressive symptoms.

The strongest finding from our review was that Omega-3 fish oil, in combination with antidepressants, had a statistically significant effect over a placebo,” said Dr. Jerome Sarris, lead author of the study, in a statement.

Many studies have shown Omega-3s are very good for general brain health and improving mood, but this is the first analysis of studies that looks at using them in combination with antidepressant medication. The difference for patients taking both antidepressants and Omega-3, compared to a placebo, was highly significant.”

The notion that supplements or vitamins could make antidepressants work better isn’t new.

One-third of patients taking antidepressants see a partial response to the drugs, and another third don’t see any results at all, making psychiatrists keen to find combinations to ameliorate their efficacy for unique patients. A few years ago, doctors started noticing that some patients on antidepressants who were also taking Deplin, a prescription medical food pill consisting of the supplement l-methylfolate, experienced a boost in their mood. For some who had not seen an improvement in symptoms from taking antidepressants alone, the medication was more effective once they added the Deplin.

Most recently, a study found that Omega-3 fatty acids helped relieve major depressive disorder, particularly among those taking antidepressants.

However, the researchers note the results should be taken with a grain of salt. It’s notoriously difficult and controversial proving nutritional supplements and vitamins effective. For that reason, the researchers encourage people to first discuss potential supplements with their doctor, especially if they’re looking to use it in collaboration with antidepressants.

We’re not telling people to rush out and buy buckets of supplements,” Sarris said in the statement. “Always speak to your medical professional before changing or initiating a treatment.”

Regardless, the researchers hope that with further research they’ll be able to develop and tailor new therapies for people whose antidepressants aren’t entirely working.

Millions of people in Australia and hundreds of millions worldwide currently take antidepressants,” Sarris said.

There’s real potential here to improve the mental health of people who have an inadequate response to them. … Medical practitioners are aware of the benefits of omega-3 fatty acids, but are probably unaware that one can combine them with antidepressant medication for a potentially better outcome.”

Source: Sarris J, et al. American Journal of Psychiatry. 2016.