Effect of supplement with lactic-acid producing bacteria on fatigue and physical activity in patients with chronic fatigue syndrome.
FAB RESEARCH COMMENT:This small open study provides preliminary evidence that supplementation with certain probiotics might help to reduce some of the mental symptoms of chronic fatigue syndrome in at least some patients, although no improvements in physical fatigue were found.
Like most psychiatric diagnoses, CFS is a highly heterogenous condition with no objective markers, and overall benefits were reported by only 6/15 patients. Future studies would therefore do well to collect both clinical and biochemical data in order to try to identify possible subgroups.
The authors also report that no major changes in GI microflora could be detected following supplementation, indicating that both dosages and formulations of the supplements used may merit further investigation.