Brain atrophy in ageing: Estimating effects of blood glucose levels vs. other type 2 diabetes effects

Walsh EI, Shaw M, Sachdev P, Anstey KJ, Cherbuin N (2017) Diabetes Metab. 2017 Jul. pii: S1262-3636(17)30468-8. doi: 10.1016/j.diabet.2017.06.004. [Epub ahead of print]

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Abstract:

It is now well documented that ageing is associated with brain shrinkage, particularly in late adulthood [1,2]. From age 60 onwards, the average adult brain atrophies ≈ 0.5%/yr for the whole brain, ≈ 0.33%/yr for grey matter and ≈ 0.62–0.68%/yr for white matter [3–5]. This may seem small, but cumulatively adds up to substantial volume losses over decades: between the ages of 60 and 70, approximately 54 mL (5%) of total brain volume is lost, a substantial amount when coupled with cumulative atrophy across the lifespan.

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Healthy glucose levels the key to a healthy ageing brain

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