Food and Behaviour Research

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Effects of Omega-3 in the treatment of violent schizophrenia patients.

Qiao Y, Mei Y, Han H, Liu F, Yang XM, Shao Y, Xie B, Long B. (2017) Schizophr Res.  Aug 19. pii: S0920-9964(17)30501-7. doi: 10.1016/j.schres.2017.08.026. [Epub ahead of print] 

Web URL: View this and related abstracts via PubMed here



This study was designed to explore the relationship in between the daily consumption of fish oil (360mg DHA+540mg EPA), and reduction of symptoms and violent behavior among patients with schizophrenia.


Fifty inpatients meeting ICD-10 criteria for schizophrenia and scoring more than four of Modified Overt Aggression Scale (MOAS) with antipsychotics treatment were randomly assigned to receive either fish oil (N=28) or a placebo (N=22) in a twelve week, double-blind supplementation trial. Assessments were performed at baseline and at weeks 4, 8 and 12.


The PANSS and CGI scores decreased at the week of 4, 8 and 12, but no differences were found between the two groups. MOAS scores declined significantly at weeks 4, 8 and 12. At week 12, MOAS scores of the fish oil group declined significantly than the placebo group (t=-2.40, P<0.05).


Violent schizophrenia patients treated with fish oil (360mg DHA+540mg EPA) demonstrated a decrease in violence, but improvement in positive and negative symptoms was no greater than patients treated with the placebo after twelve weeks.



This study adds to the existing evidence from randomised controlled trials (involving a range of different populations and measures) that an increased intake of omega-3 can help to reduce aggression, violence or other forms of antisocial behaviour. 

For a systematic review of earlier studies, see:
And for more information on this subject, please see: