Food and Behaviour Research

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The value and significance of 25(OH) and 1,25(OH) vitamin D serum levels in adult coeliac patients: A review of the literature

Zingone F, Ciacci C (2018) Dig Liver Dis.  2018 Aug;50(8): 757-760. doi: 10.1016/j.dld.2018.04.005. Epub 2018 Apr 13. 

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Within the wide spectrum of symptoms and alteration of systems that characterizes CeD, several studies indicate a low-level of vitamin D, therefore recent guidelines suggest its evaluation at the time of diagnosis.

This review examines the data from existing studies in which vitamin D has been assessed in CeD patients.

Our review indicates that most of the studies on vitamin D in adult CeD report a 25 (OH) vitamin D deficiency at diagnosis that disappears when the patient goes on a gluten-free diet, independently of any supplementation. Instead, when the calcitriol, the active 1,25 (OH) vitamin D form, was evaluated, it resulted in the normal range at the time of CeD diagnosis.

A strict and lifelong gluten-free diet can help recover vitamin D level without any supplementation.