Food and Behaviour Research

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High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice

Peri-Okonny PA, Baskin KK, Iwamoto G, Mitchell JH, Smith SA, Kim HK, Szweda LI, Bassel-Duby R, Fujikawa T, Castorena CM, Richardson J, Shelton JM, Ayers C, Berry JD, Malladi VS, Hu M-C, Moe OW, Scherer PE, Vongpatanasin W (2019) Circulation 2019 Jan; 

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Inorganic phosphate (Pi) is used extensively as a preservative and flavour enhancer in the Western Diet. Physical inactivity, a common feature of Western societies, is associated with increased cardiovascular morbidity and mortality. It is unknown whether dietary Pi excess cotributes to exercise intolerance and physical inactivity.

This research set out to determine whether or not there was such an association.


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