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9 June 2020 - MedicalXpress - Antioxidants in brain linked to improved psychosis treatment

University of Western Ontario

Brain abstract

Patients with higher levels of an antioxidant called glutathione respond more quickly to medication for psychosis and have improved outcomes. It is estimated that a 10 percent increase in antioxidants could lead to a reduction in length of hospital stay by at least seven days.


This brain imaging study showed that in people receiving medications for a first epsiode of psychosis, symptom reductions occurred sooner in those with higher concentrations of an important antioxidant - glutathione - in brain regions associated with emotional regulation.

As the researchers noted, brain levels of glutathione vary between individuals, and can be influenced by lifestyle and diet (including supplements). While this study was purely observational, other studies have reported that dietary supplementation with N-acetyl-cysteine, which can increase glutathione production, can help reduce symptoms in people with first-episode psychosis (typically schizophrenia, bipolar disorder or other serious mental health conditions).   

As usual, findings in this area have been mixed, but safe and effective interventions to improve the management of psychotic symptoms remain urgently needed.  Further investigations into the potential role of oxidative stress in the development of psychosis, and of antioxidants in recovery and treatment response, therefore appear worthwhile. 
For more details of this research study, see:

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Once patients with psychosis start treatment, some get better in weeks while it can take months for others.

Seeking to understand and influence this disparity, Schulich School of Medicine & Dentistry professor Dr. Lena Palaniyappan and his team are exploring specific chemicals in the brain with the aim of speeding up the time it takes a patient to respond to medication.

Past research has shown that patients who experience their first episode of psychosis and respond early to treatment have better overall outcomes. This includes improved symptoms and daily functioning as well as spending less time in hospital.

The research team from Schulich and Lawson Health Research Institute looked specifically at antioxidant levels in the brain and found that these chemicals which rid the body of normal metabolic by-products, called free radicals, may improve outcomes of early intervention in psychosis.

They looked specifically at an area of the brain called cingulate cortex which is well connected to a network of regions that play a major role in generating symptoms of psychosis.

The findings showed that patients with higher levels of an antioxidant called glutathione responded more quickly to medication for psychosis and had improved outcomes. They estimated that a 10 percent increase in antioxidants could lead to a reduction in length of hospital stay by at least seven days.

"This study demonstrates that if we can find a way to boost the amount of antioxidants in the brain, we might be able to help patients transition out of hospital more quickly, reduce their suffering more quickly and help them return earlier to their work and studies," said Palaniyappan, the Tanna Schulich Endowed Chair in Neuroscience and Mental Health at Western.

Antioxidant levels in the brain vary naturally from person to person and those variations can be attributed to lifestyle choices like exercise and diet. There are also ways to pharmaceutically boost these levels. A supplement called N-Acetyl Cysteine (NAC) as well as broccoli extracts can increase the brain's antioxidants if given over a long period of time.

Palaniyappan and his team in collaboration with Dr. Jean Theberge at Lawson Imaging used high-field MRI imaging to examine antioxidant levels in the brains of 37 new patients to the Prevention and Early Intervention for Psychoses Program (PEPP) at London Health Sciences Centre. Antioxidant levels were studied prior to beginning treatment for psychosis and followed up for six months post-treatment.

The study, "Early treatment response in first episode psychosis: a 7-T magnetic resonance spectroscopic study of glutathione and glutamate," was published in Nature Molecular Psychiatry.