Veurink G, Perry G, Singh SK (2020) Open Biology 17 June 2020 doi.org/10.1098/rsob.200084
Focusing research efforts, drug development strategies and healthcare approaches on a single component of a system, rather than the interacting network of components comprising such a system, may obscure important factors and/or disease mechanisms, including those evident during presymptomatic stages of disease. A holistic approach to healthcare to delay and prevent chronic diseases such as AD by lifestyle changes which optimize individual dietary needs is imperative. The MeDi has been shown to play a role in various factors involved in the pathogenesis of AD including oxidative stress and inflammation. Higher adherence to the diet by Sicilians has resulted in increased numbers of centenarians with a reduced risk for AD. Complex phenolic, carotenoid, antioxidants such as vitamin C and vitamin E are found in high concentrations in the MeDi.
In considering the multifactorial nature of AD, it may suggest that AD, like other neurodegenerative diseases and probably all degenerative diseases, may have a common link. Thus, the joint attack on the body by metabolic acidosis and oxidative stress may require a normalizing of extracellular and intracellular pH with simultaneous supplementation of a combination of antioxidants at sufficiently high personalized doses and a nutrient-rich, low-carbohydrate diet.