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Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study

Voltas N, Canals J, Hernández-Martínez C, Serrat N, Basora J, Arija V (2020) Nutrients 2020 Oct 19;12(10) DOI: 10.3390/nu12103196 

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Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills).

From an initial sample of 793 women (mean age 30.6) recruited before the 12th week of pregnancy, 422 mother-infant pairs were followed up to a postpartum visit. Vitamin D levels were assessed in the first and third trimesters of pregnancy, and socio-demographic, nutritional, and psychological variables were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III were administered to the infants and several obstetrical data were recorded.

Independently from several confounding factors, deficient vitamin D levels in the first trimester of pregnancy (
Vitamin D deficiency was therefore associated with worse neurodevelopmental outcomes. More studies are needed to determine specific recommendations with regard to vitamin D supplementation during pregnancy in order to promote an optimal course for pregnancy and optimal infant neurodevelopment.