Food and Behaviour Research

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Omega-3 fatty acids prevent early-life antibiotic exposure-induced gut microbiota dysbiosis and later-life obesity

Kaliannan K, Wang B, Li X-Y, Bhan A, Kang J (2016) International Journal of Obesity doi: 10.1038/ijo.2016.27  

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Abstract:

Early-life antibiotic exposure can disrupt the founding intestinal microbial community and lead to obesity later in life.

Recent studies show that omega-3 fatty acids can reduce body weight gain and chronic inflammation through modulation of the gut microbiota. We hypothesize that increased tissue levels of omega-3 fatty acids may prevent antibiotic-induced alteration of gut microbiota and obesity later in life.

Here, we utilize the fat-1 transgenic mouse model, which can endogenously produce omega-3 fatty acids and thereby eliminates confounding factors of diet, to show that elevated tissue levels of omega-3 fatty acids significantly reduce body weight gain and the severity of insulin resistance, fatty liver and dyslipidemia resulting from early-life exposure to azithromycin.

These effects were associated with a reversal of antibiotic-induced dysbiosis of gut microbiota in fat-1 mice.

These results demonstrate the beneficial effects of omega-3 fatty acids on antibiotic-induced gut dysbiosis and obesity, and suggest the potential utility of omega-3 supplementation as a safe and effective means for the prevention of obesity in children who are exposed to antibiotics.