Dietary fat and low fiber in purified diets differently impact the gut-liver axis to promote obesity-linked metabolic impairments
Daniel N, Perazza L, Varin T, Trottier J, Marcotte B, St-Pierre P, Barbier O, Chassaing B, Marette A (2021) American Journal of Physiology, Gastrointestinal and Liver Physiology Jun 1;320(6):G1014-G1033 doi: 10.1152/ajpgi.00028.2021
Selecting the most relevant control diet is of critical importance for metabolic and intestinal studies in animal models. Chow and LF-purified diet differentially impact metabolic and gut microbiome outcomes resulting in major changes in intestinal integrity in LF-fed animals which contributes to altering metabolic homeostasis. Dietary fat and low fiber both contribute to the deleterious metabolic effect of purified HF diets through both selective and overlapping mechanisms.
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