Food and Behaviour Research

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Why eating more sugar can leave you with LESS energy

by Van Andel Research Institute

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Too many sugary foods and drinks damage your mitochondria - the producers of cell energy

FAB RESEARCH COMMENT:

Tiny powerplants in each cell, called mitochondria, produce the energy our cells need to survive and function properly - and excess sugar reduces their efficiency.

This new study shows that high-sugar diets change the structure of mitochondrial membranes - replacing healthy, polyunsaturated fats (PUFA) with other fats that can't do the job properly.  The result is reduced energy production and metabolic problems - which over time will contribute to increasing ill health and chronic disease.

Consuming sugary foods or drinks may seem to boost energy - at least in the short-term. But rapidly rising blood sugar levels cause the release of insulin, which brings them down again.  The resulting 'rollercoaster' effect can impair energy levels, attention, concentration and mood even on a daily basis - and over time, high sugar diets are already well known to raise risks for Type 2 diabetes and many other chronic health conditions.

What this new research adds is an understanding of how excess sugar can actually damage the ability of cells to produce energy.

The authors note that their findings also help to explain why high-sugar diets can reduce the effectiveness of supplements containing omega-3 and/or omega-6 PUFA, so that higher intakes may be needed.  Adequate levels of these fats are needed for the normal function of all cell membranes, but particularly those of the brain and nervous system.  

This study was carried out in mice specially selected for their ability to absorb glucose, but the basic mechanisms it uncovered are likely to apply to other animals, including humans.

For details of the research, see:

The average American eats roughly 22 teaspoons of added sugar a day — more than three times the recommended amount for women and more than double the recommended amount for men.

Although this overconsumption is known to contribute to Type 2 diabetes and other disorders, the exact ways in which eating too much sugar sets the stage for metabolic diseases on a cellular level has been less clear.

Now, a team led by Van Andel Institute scientists has found that surplus sugar may cause our cellular powerplants — called mitochondria— to become less efficient, reducing their energy ouput.

The findings, published today in Cell Reports, highlight the cellular implications of excessive sugar consumption and provide an important new model to study the initial metabolic events that may contribute to diabetes development.

“The body needs sugar, or glucose, to survive, but, as the saying goes: ‘All good things in moderation,’” said Ning Wu, Ph.D., an assistant professor at Van Andel Institute and corresponding author of the study. “We found that too much glucose in cells, which is directly linked to the amount of sugar consumed in one’s diet, affects lipid composition throughout the body, which in turn affects the integrity of mitochondria. The overall effect is a loss of optimal function.”

Using their new model, Wu and her colleagues demonstrated that excess glucose reduces the concentration of polyunsaturated fatty acids (PUFAs) in the mitochondrial membrane and makes mitochondria less efficient. PUFAs are vital players in supporting mitochondrial function and mediating a host of other biological processes such as inflammation, blood pressure and cellular communication.

Instead, excess glucose is synthesized into a different form of fatty acid that isn’t as efficient or as flexible as PUFAs. This upends the lipid composition of the membrane and puts stress on the mitochondria, damaging them and impacting their performance.

Wu and her colleagues were able to reverse this detrimental effect by feeding their mouse models a low-sugar ketogenic diet, which suggests that reducing glucose and restoring normal membrane lipid composition supports healthy mitochondrial integrity and function. They also found that consuming excess carbohydrates reduces the beneficial effect of PUFA supplements.

“Although we may not always notice the difference in mitochondrial performance right away, our bodies do,” Wu explained. “If the lipid balance is thrown off for long enough, we may begin to feel subtle changes, such as tiring more quickly.

"While our study does not offer medical recommendations, it does illuminate the early stages of metabolic disease and provides insights that may shape future prevention and therapeutic efforts.”