FAB RESEARCH COMMENT:
Previously published results from this randomised controlled clinical trial have already shown benefits for the visual and cognitive development of infants during their first year of life if their mothers were suppemented with choline at twice
the recommended daily intake (which the placebo group received). See:
This new study confirms that these advantages of early high-dose choline supplementation for children's brain development were still evident when the children reached 7 years of age.
These findings strongly indicate that the current dietary recommendations for 'adequate' choline intake are too low to support optimal brain development. And yet choline intake for most of the general population - including 70-90% of pregnant women - falls below this level.
These are remarkable results, as clinical trials in humans are extremely
difficult to achieve with such long-term follow up.
They are also fully consistent with a huge body of existing evidence from animal studies, showing that choline deficiencies in early life permanently impair brain development and cognition.
For the related news article please see:
For further information on this topic please see:
These open-access reviews outline the functions of choline, its main dietary sources (primarily animal-derived foods), and the implications of deficiencies - particularly in early life, when these can permanently impair brain development and function according to an extensive body of pre-clinical and some human studies.
Both explain why the ongoing failure of regulatory authorities to do more to recognise and raise awareness of the essentiality of choline - particularly in the face of low and declining intakes - is potentially a serious public health problem.
In this freely available online presentation, FAB's Dr Alex Richardson provides a summary overview of choline, with a particular focus on how DHA and choline work together for normal brain development.
This talk also includes advance coverage of key findings from this newly published study (provided in advance by the authors), as well as its background and rationale.