Food and Behaviour Research

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Professor Margaret Rayman

Margaret Rayman

Professor of Nutritional Medicine, University of Surrey

Research Interests:

Professor Margaret Rayman has a doctorate in Inorganic Biochemistry from Somerville College, Oxford and has held post-doctoral fellowships at the Institute of Cancer Research and Imperial College. She is now Professor of Nutritional Medicine at the University of Surrey where she founded the highly respected MSc Programme in Nutritional Medicine.

Her research centres on the importance of trace elements to human health, with particular emphasis on selenium in prostate cancer and the pregnancy disease pre-eclampsia. She is also investigating the relationship between selenium, iodine and thyroid function. With Dr Sarah Bath, she has recently carried out pioneering studies into the iodine status of UK women during pregnancy and its implications for their children's brain development and cognitive functioning.

Teaching

  • BSc degree programmes in Nutrition, Nutrition & Dietetics, Nutrition & Food Science: lecture topics include selenium, iodine and manganese.
  • MSc Nutritional Medicine.

Her major contribution to teaching in the University has been the creation of the very successful Nutritional Medicine post-graduate programme, the first (and still unique) university-level, evidence-based course in the UK designed for the in-service training of doctors and other health professionals in the use of nutritional methods of disease prophylaxis and management.

The Programme, of which she is Director, has now been running for 16 years during which time it has been extremely successful, achieving a high profile and excellent reputation. It draws a considerable number of students from Europe and from countries as far away as China, Canada and South Africa. Currently there are over 150 registered part-time students, the majority of whom are practising clinicians, including consultants, and a substantial number of gastroenterologists.

  • She organises a number of MSc Nutritional Medicine modules and lecture on topics including selenium, iodine, osteo- and rheumatoid arthritis; diet and prostate cancer; pre-eclampsia.

Recent Publications:

Mao J, Bath SC, Vanderlelie JJ, Perkins AV, Redman CW, Rayman MP. (2015) No effect of modest selenium supplementation on insulin resistance in UK pregnant women, as assessed by plasma adiponectin concentration. Br J Nutr, Oct 20:1-7. [Epub ahead of print]

Cold F, Winther KH, Pastor-Barriuso R, Rayman MP, Guallar E, Nybo M, Griffin BA, Stranges S, Cold S. (2015) Randomised controlled trial of the effect of long-term selenium supplementation on plasma cholesterol in an elderly Danish population, Br J Nut., Sep 30:1-12. [Epub ahead of print]

Wu Q, Rayman MP, Lv H, Schomburg L, Cui B, Gao C, Chen P, Zhuang G, Zhang Z, Peng X, Li H, Zhao Y, He X, Zeng G, Qin F, Hou P, Shi B. (2015) Low population selenium status is associated with increased prevalence of thyroid disease. J Clin Endocrinol Metab, Aug 25:jc20152222. [Epub ahead of print]

Rayman MP, Bath SC. (2015) The new emergence of iodine deficiency in the UK: consequences for child neurodevelopment. Ann Clin Biochem, Nov;52(Pt 6):705-8. 

Bath SC, Furmidge-Owen VL, Redman CW, Rayman MP.(2015) Gestational changes in iodine status in a cohort study of pregnant women from the United Kingdom: season as an effect modifier. Am J Clin Nutr, Jun;101(6):1180-7.

Bath SC, Rayman MP.(2015) A review of the iodine status of UK pregnant women and its implications for the offspring. Environ Geochem Health, Aug;37(4):619-29.

Rayman MP, Bath SC, Westaway J, Williams P, Mao J, Vanderlelie JJ, Perkins AV, Redman CW. (2015) Selenium status in UK pregnant women and its relationship with hypertensive conditions of pregnancy. Br J Nutr, Jan 9:1-10. [Epub ahead of print]

Conaghan PG, Porcheret M, Kingsbury SR, Gammon A, Soni A, Hurley M, Rayman MP, Barlow J, Hull RG, Cumming J, Llewelyn K, Moscogiuri F, Lyons J, Birrell F.(2015)
Impact and therapy of osteoarthritis: the Arthritis Care OA Nation 2012 survey.
Clin Rheumatol, Sep;34(9):1581-8.

Mao J, Pop VJ, Bath SC, Vader HL, Redman CW, Rayman MP. (2014) Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency. Eur J Nutr, Dec 19. [Epub ahead of print]

Bath SC, Sleeth ML, McKenna M, Walter A, Taylor A, Rayman MP. (2014) Iodine intake and status of UK women of childbearing age recruited at the University of Surrey in the winter. Br J Nutr, Nov 28;112(10):1715-23.

Rayman MP, Searle E, Kelly L, Johnsen S, Bodman-Smith K, Bath SC, Mao J, Redman CW.(2014) Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: a randomised, controlled pilot trial. Br J Nutr, Jul 14;112(1):99-111. 

Geybels MS, van den Brandt PA, Schouten LJ, van Schooten FJ, van Breda SG, Rayman MP, Green FR, Verhage BA.(2014) Selenoprotein gene variants, toenail selenium levels, and risk for advanced prostate cancer. J Natl Cancer Inst., Mar;106(3)

Bath SC, Walter A, Taylor A, Wright J, Rayman MP.(2014) Iodine deficiency in pregnant women living in the South East of the UK: the influence of diet and nutritional supplements on iodine status. Br J Nutr, May;111(9):1622-31.

Bath SC, Rayman MP. (2013) Iodine deficiency in the U.K.: an overlooked cause of impaired neurodevelopment? Proc Nutr Soc., May;72(2):226-35. 

Bath SC, Jolly KB, Rayman MP.(2013) Iodine supplements during and after pregnancy.
JAMA. 2013 Apr 3;309(13):1345

Bath SC, Rayman MP. (2012) Antenatal thyroid screening and childhood cognitive function. N Engl J Med, Apr 26;366(17):1640-1; author reply 1641.

Rayman MP. (2012) Selenium and human health. Lancet, Mar 31;379(9822):1256-68. 

Bath SC, Button S, Rayman MP. (2012) Iodine concentration of organic and conventional milk: implications for iodine intake. Br J Nutr, Apr;107(7):935-40.

Bath S, Rayman MP. (2011) Iodine deficiency in UK schoolgirls. Lancet, Nov 5;378(9803):1623; author reply 1624. 

Rayman MP, Stranges S, Griffin BA, Pastor-Barriuso R, Guallar E. (2011) Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial.
Ann Intern Med, May 17;154(10):656-65.

Stranges S, Tabák AG, Guallar E, Rayman MP, Akbaraly TN, Laclaustra M, Alfthan G, Mussalo-Rauhamaa H, Viikari JS, Raitakari OT, Kivimäki M. (2011). Selenium status and blood lipids: the cardiovascular risk in Young Finns study. J Intern Med, Nov;270(5):469-77. Free PMC Article

Rayman MP, Wijnen H, Vader H, Kooistra L, Pop V. (2011). Maternal selenium status during early gestation and risk for preterm birth.
CMAJ, Mar 22;183(5):549-55.

Stranges S, Navas-Acien A, Rayman MP, Guallar E. (2010) Selenium status and cardiometabolic health: state of the evidence. Nutr Metab Cardiovasc Dis, Dec;20(10):754-60.

Tara F, Maamouri G, Rayman MP, Ghayour-Mobarhan M, Sahebkar A, Yazarlu O, Ouladan S, Tavallaie S, Azimi-Nezhad M, Shakeri MT, Boskabadi H, Oladi M, Sangani MT, Razavi BS, Ferns G. (2010) Selenium supplementation and the incidence of preeclampsia in pregnant Iranian women: a randomized, double-blind, placebo-controlled pilot trial. Taiwan J Obstet Gynecol. Jun;49(2):181-7.

Tara F, Rayman MP, Boskabadi H, Ghayour-Mobarhan M, Sahebkar A, Alamdari DH, Razavi BS, Tavallaie S, Azimi-Nezhad M, Shakeri MT, Oladi M, Yazarlu O, Ouladan S, Sangani MT, Omran FR, Ferns G. (2010) Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation. J Perinat Med, Sep;38(5):473-8.

Mokhber N, Namjoo M, Tara F, Boskabadi H, Rayman MP, Ghayour-Mobarhan M, Sahebkar A, Majdi MR, Tavallaie S, Azimi-Nezhad M, Shakeri MT, Nematy M, Oladi M, Mohammadi M, Ferns G. (2011) Effect of supplementation with selenium on postpartum depression: a randomized double-blind placebo-controlled trial. J Matern Fetal Neonatal Med, Jan;24(1):104-8. doi: 10.3109/14767058.2010.482598. Epub 2010 Jun 8. PMID: 20528216

Akbaraly TN, Arnaud J, Rayman MP, Hininger-Favier I, Roussel AM, Berr C, Fontbonne A. (2010) Plasma selenium and risk of dysglycemia in an elderly French population: results from the prospective Epidemiology of Vascular Ageing Study. Nutr Metab (Lond), Mar 18;7:21. Free PMC Article

Tara F, Rayman MP, Boskabadi H, Ghayour-Mobarhan M, Sahebkar A, Yazarlu O, Ouladan S, Tavallaie S, Azimi-Nezhad M, Shakeri MT, Teymoori MS, Razavi BS, Oladi M, Ferns G. (2010). Selenium supplementation and premature (pre-labour) rupture of membranes: a randomised double-blind placebo-controlled trial. J Obstet Gynaecol, Jan;30(1):30-4. 

Johnson CC, Fordyce FM, Rayman MP. (2010) Symposium on 'Geographical and geological influences on nutrition': Factors controlling the distribution of selenium in the environment and their impact on health and nutrition. Proc Nutr Soc. 2010 Feb;69(1):119-32. 

Rayman MP, Combs GF Jr, Waters D. Selenium and Vitamin E Supplementation for Cancer Prevention. JAMA. 2009;(301):1876 (doi:10. 1001/jama.2009.645).

Rayman MP. Selenoproteins in human health: insights from epidemiological data. Biochim Biophys Acta. 2009 Mar 25.

Bekaert B, Rayman MP. Plasma selenium concentration and prostate cancer risk. Am J Clin Nutr. 2009 Apr;89(4):1276-7. Epub 2009 Feb 11.

Cooper ML, Adami H-O, Grönberg H, Wiklund F, Green FR, Rayman MP. Interaction between SNPs in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk. Cancer Res 2008 Dec 15;68(24):10171-7.

Bekaert B, Cooper ML, Green FR, McNulty H, Pentieva K, Scott JM, Molloy AM, Rayman MP. Effect of selenium status and supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly. Mol Nutr Food Res. 2008 Aug 6.

Bath S, Walter A, Taylor A, Rayman M. Iodine status of UK women of childbearing age. J Hum Nutr Diet. 2008 Jul 15;21(4):379-380.

Rayman MP, Pattison DJ. Dietary manipulation in musculoskeletal conditions. Best Pract Res Clin Rheumatol. 2008 Jun;22(3):535-61.

Rayman MP. Food-chain selenium and human health: emphasis on intake. Br J Nutr. 2008 Aug;100(2):254-68. Epub 2008 Mar 18.

Rayman MP, Infante HG, Sargent M. Food-chain selenium and human health: spotlight on speciation. Br J Nutr. 2008 Aug;100(2):238-53. Epub 2008 Mar 18.

Rayman MP, Thompson AJ, Bekaert B, Catterick J, Galassini R, Hall E, Warren-Perry M, Beckett GJ. Randomized controlled trial of the effect of selenium supplementation on thyroid function in the elderly in the United Kingdom. Am J Clin Nutr. 2008 Feb;87(2):370-8.

Shaheen S, Newson R, Rayman M, Wong A, Tumilty M, Phillips J, Potts J, Kelly F, White P, Burney P (2007) Randomised, double-blind, placebo-controlled trial of selenium supplementation in adult asthma. Thorax 62: 483-90.

Goenaga Infante H, O'Connor G, Rayman M, Hearn R, Cook K (2006) Simultaneous identification of selenium-containing glutathione species in selenised yeast by on-line HPLC with ICP-MS and electrospray ionisation quadrupole time of flight (QTOF)-MS/MS. J Anal At Spectrom, 21: 1256 - 1263.

Rayman MP, Thompson A, Warren-Perry M, Galassini R, Catterick J, Bliss J, Hall E, Lawrence D (2006) Impact of selenium on mood and quality of life: a randomised controlled trial. Biol Psychiatry; 59:147-54.

Rayman MP (2005) Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc 64: 527-542.

Goenaga Infante H, O'Connor G, Rayman M, Wahlen R, Spallholz J, Hearn R, Catterick T (2005) Identification of water-soluble g-glutamyl-Se-methylselenocysteine in yeast-based selenium supplements by reversed-phase HPLC with ICP-MS and electrospray tandem MS detection. J Anal Atom Spectrom 20, 864 - 870.

Goenaga Infante H, O'Connor G, Rayman M, Wahlen R, Spallholz J, Hearn R, Catterick T (2005) Identification of water-soluble g-glutamyl-Se-methylselenocysteine in yeast-based selenium supplements by reversed-phase HPLC with ICP-MS and electrospray tandem MS detection. J Anal Atom Spectrom 20, 864 - 870.

Rayman MP (2004) The use of high-selenium yeast to raise selenium status: how does it measure up? British Journal of Nutrition 92: 557-573.

Heidi Goenaga Infante, Gavin O'Connor, Margaret Rayman, Raimund Wahlen, John Entwisle, Paul Norris, Ruth Hearn and Tim Catterick (2004) Selenium speciation analysis of selenium-enriched supplements by HPLC with ultrasonic nebulisation ICP-MS and electrospray MS/MS detection. J Anal Atom Spectrom. 19, 1529 - 1538.

Rayman MP, Bode P, Redman CWG (2004) Low selenium is associated with the occurrence of preeclampsia in women from the United Kingdom. Letter to the editor. Am J Obs Gynecol 191: 676-7.

Larsen EH, Hansen M, Paulin H, Moesgaard S, Reid M, Rayman MP (2004) Speciation and bioavailability of selenium in yeast-based intervention agents used in cancer chemo-prevention studies. Journal of Association of Official Analytical Chemists International 87: 225-32.

Rayman MP, Bode P, Redman CWG (2003) Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in UK women. American Journal of Obstetrics and Gynecology 189: 1343-9.

Rayman MP (2002) The argument for increasing selenium intake. Proc Nutr Soc, 61: 203-215. Rayman MP, Barlis J, Evans RW, Redman CWG, King LJ (2002) Abnormal iron parameters in the pregnancy syndrome pre-eclampsia. American Journal of Obstetrics and Gynecology 187: 412-8.