Food and Behaviour Research

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Vitamin D, cognition, and dementia: A systematic review and meta-analysis

Balion C, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, Llewellyn DJ, Raina P (2012) Neurology. 2012 Sep 25;79(13):1397-405   

Web URL: View this and related abstracts via PubMed here

Abstract:

OBJECTIVE:

To examine the association between cognitive function and dementia with vitamin D concentration in adults.

METHODS:

Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of global or domain-specific cognitive performance and dementia was diagnosed according to recognized criteria. A vitamin D measurement was required. Two authors independently extracted data and assessed study quality using predefined criteria. The Q statistic and I(2) methods were used to test for heterogeneity. We conducted meta-analyses using random effects models for the weighted mean difference (WMD) and Hedge's g.

RESULTS:

Thirty-seven studies were included; 8 contained data allowing mean Mini-Mental State Examination (MMSE) scores to be compared between participants with vitamin D

CONCLUSION:

These results suggest that lower vitamin D concentrations are associated with poorer cognitive function and a higher risk of AD. Further studies are required to determine the significance and potential public health benefit of this association.