Food and Behaviour Research

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A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice

Aksenov V, Long J, Liu J, Szechtman H, Khanna P, Matravadia S, Rollo CD (2011) Age (Dordr). 2011 Nov 27. [Epub ahead of print]   

Web URL: View this abstract and related citations on PubMed here


We developed a complex dietary supplement designed to offset five key mechanisms of aging and tested its effectiveness in ameliorating age-related cognitive decline using a visually cued Morris water maze test.

All younger mice (1 year) were unable to learn the maze even after 5 days, indicative of strong cognitive decline at older ages. In contrast, no cognitive decline was evident in older supplemented mice, even when ∼2 years old. Supplemented older mice were nearly 50% better at locating the platform than age-matched controls.

Brain weights of supplemented mice were significantly greater than controls, even at younger ages. Reversal of cognitive decline in activity of complexes III and IV by supplementation was significantly associated with cognitive improvement, implicating energy supply as one possible mechanism.

These results represent proof of principle that complex dietary supplements can provide powerful benefits for cognitive function and brain aging.