Tveden-Nyborg P, Lykkesfeldt J. (2009) Redox Rep. 14(1) 2-6
Scurvy, the rare but potentially mortal manifestation of severe and prolonged lack of vitamin C, is often confused with hypovitaminosis C, i.e. the mere definition of vitamin C deficiency.
While the latter condition can be diagnosed in millions, the clinical consequences (if they exist) remain largely unknown, since only a tiny fraction of those deficient in vitamin C actually develop clinical scurvy.
Is hypovitaminosis C itself a problem at all then? Yes, it may well be in some cases.
Recent data from our laboratory suggest that the neonatal brain is particularly susceptible to vitamin C deficiency and that this condition may adversely affect early brain development.
See also: Tveden-Nyborg et al 2009 - Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs