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Improvement in neuroleptic-induced akathisia with intravenous iron treatment in a patient with iron deficiency

Cotter PE, O'Keeffe ST. (2007) J Neurol Neurosurg Psychiatry.  78(5): 548. 

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Iron deficiency may play a role in the pathogenesis of drug-induced akathisia, but the evidence is conflicting.1,2,3 There have been no reports of the effect of iron treatment in this condition. We report the case of a patient with iron deficiency whose akathisia had not responded to standard interventions but did respond dramatically to intravenous iron treatment.

1.Brown K W, Glen S E, White T. Low serum iron status and akathisia. Lancet 1987,1,1234-1236.

2. Barnes T R, Halstead S M, Little P W. Relationship between iron status and chronic akathisia in an in-patient population with chronic schizophrenia.Br J Psychiatry, 1992.

3.Kuloglu M, Atmaca M, Ustundag B. et al Serum iron levels in schizophrenic patients with or without akathisia. Eur Neuropsychopharmacol 2003,13,67-71.