Sokolov OIu, Kost NV, Kurasova OB, Dmitriev AD, Gabaeva MV, Zolotarev IuA, Mikheeva IG, Zozulia AA. (2007) Vestn Ross Akad Med Nauk. (3) 33-9.
Regulatory peptides (RP) are an important homeostatic factor. The maternal organism and placenta are substantial sources of RP for fetus during the prenatal period. Not only endogenous, but also exogenous RP play an important role during early postnatal period.
In this study, the concentration of exogenous RP (casomorphins-7) and the activity of peptidases (enkephalinases) in the serum of breastfed and bottle-fed infants were estimated. Possible interrelation between these two parameters and the psychomotor development (PMD) of infants were evaluated. Using specially developed RIA, the investigators estimated the presence of human and bovine casomorphins immunoreactivity (CMir) in the serum of breastfed and bottle-fed infants.
A distinct correlation of CMir with PMD was demonstrated. The activity of RP-degrading serum enzymes also correlated with PMD level.
The role of endo- and exogenous peptides in normal PMD process and in the pathogenesis of early child autism is discussed in the article.