Food and Behaviour Research

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Regulation of metabolic rate and substrate utilization by zinc deficiency.

Evans SA, Overton JM, Alshingiti A, Levenson CW. (2004) Metabolism. 53(6) 727-32 

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The trace metal zinc (Zn) is essential for the catalytic activity of many enzymes involved in energy nutrient metabolism and appears to regulate hormones, such as insulin, leptin, and thyroid hormone that play key roles in metabolism. Thus, this study used the continuous monitoring of oxygen consumption, carbon dioxide production, locomotion, and food intake to determine the effect of dietary Zn restriction on metabolic rate (MR), basal metabolic rate (BMR), and respiratory quotient (RQ). Rats were fed a Zn-adequate (ZA, 28 ppm) or Zn-deficient (ZD, <1 ppm) diet for 8 days, followed by a 4-day refeeding period. to control reductions in food intake that characteristically occur zd rats, an additional group was pair-fed (pf) the same amount za eaten rats. mean caloric of rats significantly lower than day 3. 8, and pf weighed 64% 67% respectively, (p <.01). pair feeding resulted increased locomotor activity, such distance traveled (316 +>