Food and Behaviour Research

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Zinc regulation of food intake: new insights on the role of neuropeptide Y

Levenson CW. (2003) Nutr Rev.  61(7) :247-9. 

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The role of neuropeptide Y (NPY) in feeding behavior and zinc deficiency-induced anorexia has been controversial because hypothalamic NPY levels are elevated in both zinc deficiency and food restriction.

A recent report shows that while NPY is released from terminals in the paraventricular nucleus of the hypothalamus of food-restricted animals, this release is significantly impaired in zinc-deficient animals.

Zinc deficiency may therefore cause anorexia by inhibiting the release of NPY that is required for receptor activation.