Food and Behaviour Research

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Identification of indolyl-3-acryloylglycine in the urine of people with autism

Anderson RJ, Bendell DJ, Garnett I, Groundwater PW, Lough WJ, Mills MJ, Savery D, Shattock PE.  (2002) Journal of Pharmacy & Pharmacology 54(2) 295-8  

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HPLC analysis of the urine of autistic subjects indicated the presence of an unidentified component in greatly increased concentrations.

We have reported the isolation of this component by HPLC and its identification.

Mass spectrometry, NMR and UV spectroscopy identified the peak as corresponding to indolyl-3-acryloylglycine (IAG, 3), and this has been confirmed by an independent synthesis.