Food and Behaviour Research

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Serum iron abnormalities in neuroleptic-induced akathisia in schizophrenic patients

Soni SD, Tench D, Routledge RC. (1993) Br J Psychiatry.  163: 669-72. 

Web URL: View this and related abstracts via PubMed here


Twenty-two schizophrenic patients (DSM-III-R criteria) with clinically significant akathisia were matched with 22 schizophrenic patients without akathisia on the following variables: age, sex, diagnosis, duration of illness, and current treatment. Both groups were assessed using a variety of clinical rating scales and several parameters of serum iron status.

The akathisic patients showed greater severity of clinical psychopathology, particularly positive symptoms, and an excess of extrapyramidal side-effects. We were unable to confirm any association between low serum iron and neuroleptic-induced akathisia in our sample of community-based patients.


Some previous small studies have found low serum iron in patients with akathisia (a common and troublesome side effect of anti-psychotic medications used in the management of serious mental health conditions like schizophrenia). See for example: 

However, this study found no clear differences between patients with or without akathisia, as was also the case in a more recent (larger) study of chronic patients. See: