Food and Behaviour Research

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Long-term neurologic consequences of nutritional vitamin B12 deficiency in infants.

Graham SM, Arvela OM, Wise GA. (1992) J Pediatr.  121(5 Pt 1): 710-4. 

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A review of the clinical findings in six infants with nutritional vitamin B12 deficiency seen during the last 10 years was undertaken and an attempt made to obtain long-term neurologic follow-up.

There was a consistent clinical pattern in vitamin B12-deficient infants; irritability, anorexia, and failure to thrive were associated with marked developmental regression and poor brain growth. Two of the four patients who qualified for long-term review had a poor intellectual outcome.

Although early response to treatment is satisfying, the long-term consequences of nutritional vitamin B12 deficiency in infants emphasize the need for prevention or early recognition of this syndrome.