Low serum iron in patients with neuroleptic-induced akathisia and dystonia under antipsychotic drug treatment

Horiguchi J. (1991) Acta Psychiatr Scand. 84(3): 301-3.

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Abstract:

The concentration of iron was determined in the serum of 35 patients; 10 with akathisia, 8 with dystonia and 17 without akathisia or dystonia.

The patients exhibiting akathisia or dystonia had significantly lower serum concentration of iron than the patients without akathisia or dystonia. Neuroleptic-induced akathisia or dystonia may be facilitated by the low serum iron.

FAB RESEARCH COMMENT:

This study's findings add to those from previous research, suggesting that iron depeletion might be one of the factors contributing to akathisia - a syndrome involving extreme motor restlessness and emotional agitation that can be a side-effect of some anti-psychotic medications.
See:

Brown Et Al 1987 - Low Serum Iron Status And Akathisia

Barton Et Al 1990 - Low Plasma Iron Status And Akathisia

O'Loughlin 1991 - Serum Iron And Transferrin In Acute Neuroleptic Induced Akathisia

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