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Extensive literature search as preparatory work for the safety assessment for caffeine

Bull S, Brown T, Burnett K, Ashdown L, Rushton L (2015) EFSA Journal   EFSA

Web URL: Read the OPEN ACCESS report on the EFSA website here

Abstract:

Previous studies on the safety of caffeine have been published by the Scientific Committee on Food (SCF) in 1983, 1999 and 2003. In the latter assessment, the SCF concluded that caffeine would not exacerbate the adverse effects of alcohol.
A recent study carried out by the Committee on toxicity of chemicals in food consumer products and the environment (COT) looked at any new data published since the SCF report and advised on the potential for interactions between caffeine and alcohol. Limited data prevented them assessing the effect of caffeine on the acute toxicity of alcohol. Overall, the committee concluded that, based on the current balance of evidence, there is no harmful toxicological or behavioural interaction between caffeine and alcohol. However, they stated that this opinion should be reviewed if new evidence emerges.
In 2013, the European Food Safety Authority (EFSA) was asked to evaluate potential adverse health effects that may arise following consumption either alone or in combination with alcohol and/or other substances such as energy drinks. Therefore, the objective of this project is to provide EFSA with an evidence base related to the adverse effects of caffeine, either alone or in combination with alcohol and/or other substances found in energy drinks in various population groups.

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15 January 2015 - EFSA - Caffeine: EFSA consults on draft assessment