Cerebrovascular and cognitive functioning peak developmentally in young adults, yet recent evidence indicates they may benefit on these fronts from regular engagement in physicalactivity. In light of epidemiological trends for increasingly sedentary lifestyles and the importance of optimal cerebrovascular and cognitive functioning, here we investigated relationships between physicalactivity levels, anteriorfrontal hemodynamics, and cognitive performance in 52 healthyyoungwomen. Analyses positively linked chronicphysicalactivity level (CPAL) with anteriorfrontaloxygenatedhemoglobin and cognitive inhibitory control, indicating regular physicalactivity may lead to hemodynamic and cognitive benefits, even in a cohort at developmental peak. In addition, higher anteriorfrontaloxygenatedhemoglobin was linked to better performance for the most difficult cognitive task. Given the importance of oxygen availability for cognitive functioning, the current discovery of a relationship with CPAL may provide important insight toward understanding exercise-cognition links.