Curl CL, Beresford SA, Fenske RA, Fitzpatrick AL, Lu C, Nettleton JA, Kaufman JD. (2015) Environ Health Perspect. DOI: 10.1289/ehp.1408197
Organophosphate pesticide (OP) exposure to the US population is dominated by dietary intake. The magnitude of exposure from diet depends partly upon personal decisions such as which foods to eat and whether to choose organic food. Most studies of OP exposure rely on urinary biomarkers, which are limited by short half-lives and often lack specificity to parent compounds. A reliable means of estimating long-termdietary exposure to individual OPs is needed to assess the potential relationship with adverse health effects.
We assessed long-term dietary exposure to 14 OPs among 4,466 participants in the Multi-Ethnic Study of Atherosclerosis, and examined the influence of organic produce consumption on this exposure.
Individual-level exposure was estimated by combining information on typical intake of specific food items with average OP residue levels on those items. In an analysis restricted to a subset of participants who reported rarely or never eating organic produce ("conventional consumers"), we assessed urinary dialkylphosphate (DAP) levels across tertiles of estimated exposure (n=480). In a second analysis, we compared DAP levels across subgroups with differing self-reported organic produce consumption habits (n=240).
Among conventional consumers, increasing tertile of estimated dietary OP exposure was associated with higher DAP concentrations (p<0.05). DAP concentrations were also significantly lower in groups reporting more frequent consumption of organic produce (p<0.02).
Long-term dietary exposure to OPs were estimated from dietary intake data, and estimates were consistent with DAP measurements. More frequent consumption of organic produce was associated with lower DAPs.
05 February 2015 - ScienceDaily - Organic food reduces pesticide exposure
Previous research has also shown links between exposure to air pollution during pregnancy and the risk of autism and related neurodevelopmental disorders. For details, see: Air pollution raises autism risk
Shelton et al 2014 - Neurodevelopmental Disorders and Prenatal Residential Proximity to Agricultural Pesticides: The CHARGE Study