Food and Behaviour Research

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Fate, activity, and impact of ingested bacteria within the human gut microbiota.

Derrien M, van Hylckama Vlieg JE (2015) Trends Microbiol.  doi: 10.1016/j.tim.2015.03.002. [Epub ahead of print] Elsevier Ltd

Web URL: Please find the OPEN ACCESS paper and related research on PubMed here


The human gut contains a highly diverse microbial community that is essentially an open ecosystem, despite being deeply embedded within thehuman body. Food-associated fermentative bacteria, including probiotics, are major sources of ingested bacteria that may temporarily complement resident microbial communities, thus forming part of our transient microbiome. Here, we review data on the fate and activity of ingested bacteria and, in particular, lactobacilli and bifidobacteria in the gastrointestinal (GI) tract and their impact on the composition and metabolism of the gut microbiome with a focus on data from clinical studies. In addition, we discuss the mechanisms involved and the potential impact on the host's health.