Food and Behaviour Research

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Sweeteners 'linked to rise in obesity and diabetes'

John Von Radowitz


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Despite containing few if any calories, artificial sweeteners have never been shown to help with actual weight loss.  And in this groundbreaking new study, good evidence has now been put forward that they can in fact contribute to metabolic syndrome, obesity and diabetes, via effects on the gut microbiota.

Given quite how prevalent artificial sweeteners now are - as regular additives in many foods as well as drinks - this remarkable finding (which was confirmed in a significant proportion of the humans studied, as well as shown in an elegant series of well-controlled animal studies) merits both wide publicity - as a matter of precaution - and further confirmatory research as a matter of urgency. 

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And for furter - and more recent - information on this topic, please see:

Sugar-free sweeteners could increase glucose intolerance and diabetes risk by affecting bacteria in the gut, a study has suggested.

Far from improving metabolism and helping people to slim, widespread use of artificial sweeteners may be fuelling the obesity and diabetes epidemic, it is claimed.

Scientists found that giving mice water laced with three commonly used sweeteners in doses corresponding to those recommended for humans caused them to develop glucose intolerance.

The condition occurs when sugar levels in the blood rise and can lead to Type-2 diabetes, which affects around 2.7 million people in the UK.

Tests showed that in mice, sweeteners altered the balance of gut microbes that have been linked to susceptibility to metabolic diseases. They also affected the composition and function of gut bacteria in a small number of human volunteers, resulting in glucose intolerance after one week.

The lead researcher, Dr Eran Elinav, from the Weizmann Institute in Rehovot, Israel, said: “This calls for reassessment of today’s massive, unsupervised consumption of these substances.”

The study, reported in the journal Nature, found that people’s reaction to sweeteners varied depending on the kind of bacteria they harboured.

Two different populations of human gut microbes were identified, one that induced glucose intolerance when exposed to the sweeteners and another that did not.

Certain bacteria reacted to artificial sweeteners by secreting substances that provoked an inflammatory response similar to a sugar overdose, the scientists believe.

British experts said the findings were interesting but urged caution. Dr Katarina Kos, senior lecturer and consultant in diabetes and endocrinology at the University of Exeter, pointed out that only seven human volunteers were studied, and that further confirmation would be needed “prior to making firm conclusions”. 

She added: “These findings support the widespread understanding that water is the healthiest option and we should avoid sweet and sweetened drinks. Water is the best drink to control blood sugar.”