Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study.
Amminger GP, Schafer MR, Schlogelhofer M, Klier CM, McGorry PD. (2015) Nature Communications 11;6 7934. doi: 10.1038/ncomms8934.
Web URL: View this and related abstracts via PubMed here. Free full text of this article is available online
Abstract:
Long-chain omega-3 polyunsaturated fatty acids (PUFAs) are essential for neural development and function. As key components of brain tissue,omega-3 PUFAs play critical roles in brain development and function, and a lack of these fatty acids has been implicated in a number of mental health conditions over the lifespan, including schizophrenia.We have previously shown that a 12-week intervention with omega-3 PUFAs reduced the risk of progression to psychotic disorder in young people with subthreshold psychotic states for a 12-month period compared with placebo. We have now completed a longer-term follow-up of this randomized, double-blind, placebo-controlled trial, at a median of 6.7 years.
Here we show that brief intervention with omega-3 PUFAs reduced both the risk of progression to psychotic disorder and psychiatric morbidity in general in this study. The majority of the individuals from the omega-3 group did not show severe functional impairment and no longer experienced attenuated psychotic symptoms at follow-up.
FAB RESEARCH COMMENT:
Free full text of this article is available from the website of Nature hereAnd for an accessible summary of this research, please see the associated news articles:
For details of the original 12-month study involving these young people, all of whom were originally judged to be at very high risk for developing psychosis, see also:
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