Metabolic Neuropsychiatry

This open access book provides an interdisciplinary perspective on energy metabolism in the brain and body in neuropsychiatric disorders and suggests future research directions.

Editors: Dost Öngür, Judith M. Ford

This impressive new open-access resource is essential for researchers and health professionals with a background in metabolic psychiatry.

Multiple lines of evidence indicate that energy metabolism is aberrant in the body and brain in individuals with major neuropsychiatric disorders such as schizophrenia, mood disorders, and neurodegenerative disorders. Emerging therapeutic interventions aim to improve outcomes in many of these common and severe disorders. To foster interdisciplinary dialogue and to promote informed applications in research, medicine, and public health, the Ernst Strüngmann Forum convened scholars from diverse fields to examine the role of energy metabolism in brain function, the bidirectional association between metabolism in the brain and body, and the future therapeutic potential of treatment interventions that improve metabolism in people with psychiatric disorders.

Synthesizing the interdisciplinary perspectives that emerged from these discussions, the book is organized in four sections:

• Role of Metabolism in Brain Function
• Metabolic Abnormalities in Neuropsychiatric Disorders
• Systemic Metabolic Aspects of Neuropsychiatric Disorders
• Metabolism-Based Therapies

This volume offers insights to researchers and clinicians working in basic, translational, and clinical research in neurology and psychiatry pertinent to mitochondrial function, energy metabolism, human physiology, and treatment development.

Preview of Chapters

Individual chapters can also be downloaded via the button above:

1. Metabolic Neuropsychiatry
2. Integrating Brain Metabolism Research into Big Data Human Neuroscience
3. Brain Energy Constraints and Vulnerability
4. Brain Energy Production: Vulnerability and Pathophysiology
5. Metabolic Abnormalities in Neuropsychiatric Disorders
6. What Is the Best Evidence for Bioenergetic Abnormalities in Severe Mental Illness?
7. Role of Metabolism in the Emergence of Neuropsychiatric Disorders
8. Systemic Mitochondrial Alterations in Alzheimer Disease Dementia
9. Links between Inflammation and Metabolism in Periphery and Brain: Lessons from Epidemiological Research on Depression
10. Metabolism across the Lifespan: Implications for Body and Mind
11. Severe Mental Illness as a Multisystem Metabolic Disorder: From Brain to Body and Back Again
12. Best Practices for Randomized Controlled Trials in Metabolic Neuropsychiatry Studies
13. Disassociating Causality in Complex Interacting Systems
14. Designing Innovative Interventions for Metabolic Neuropsychiatry