Food and Behaviour Research

Donate Log In

Sleep and Diet: Why Sleep Matters for Wellbeing and its Links with Nutrition - BOOK HEREE

Microbial metabolism of L-tyrosine protects against allergic airway inflammation

Wypych T, Pattaroni C, Perdijk O, Yap C, Trompette A, Anderson D, Creek D, Harris N, Marsland B (2021) Nature Immunology DOI: 10.1038/s41590-020-00856-3  

Web URL: Read this and related articles on Nature


The constituents of the gut microbiome are determined by the local habitat, which itself is shaped by immunological pressures, such as mucosal IgA.

Using a mouse model of restricted antibody repertoire, we identified a role for antibody–microbe interactions in shaping a community of bacteria with an enhanced capacity to metabolize 

This model led to increased concentrations of 
p-cresol sulfate (PCS), which protected the host against allergic airway inflammation. PCS selectively reduced CCL20 production by airway epithelial cells due to an uncoupling of epidermal growth factor receptor (EGFR) and Toll-like receptor 4 (TLR4) signaling.

Together, these data reveal a gut microbe–derived metabolite pathway that acts distally on the airway epithelium to reduce allergic airway responses, such as those underpinning asthma.


For the related news article please see: