Supplementation with CO induces lipogenesis in adipose tissue, leptin and insulin resistance in healthy Swiss mice

Veras A, Bruzasco L, Lopes A, Franco B, Holanda A, Esteves A, Milanski M, Torsoni A, Ignacio-Souza L, Torsoni M (2023) Journal of Functional Foods Volume 106 Doi: 10.1016/j.jff.2023.105600

Web URL: Read this on Science Direct

Abstract:

The consumption of saturated fatty acids (SFA), the main compound in coconut oil (CO), can promote insulin and leptin resistance and are associated with inflammation and obesity.

We investigated the effects of CO supplementation on leptin signaling in healthy mice. Swiss male mice received oral supplementation for eight weeks with 300 μL of water for the control group (CV) or CO (100 or 300 μL). Sensitivity to leptin/insulin was evaluated after eight weeks of supplementation.

The CO induced endoplasmic reticulum stress and leptin resistance in the hypothalamus, as demonstrated by reduced effect on the energy expenditure, hypothalamic pJAK2 and pSTAT3, and POMC expression. In the adipose tissue, lipogenesis was favored and STAT3 and JAK2 signaling was impaired after CO supplementation. Furthermore, the supplementation with CO reduced pAKT in the hypothalamus, liver and white adipose tissue.

These results show that CO induces hypothalamic and peripheral resistance to leptin and insulin in healthy mice.

FAB RESEARCH COMMENT:

For the related news article:

Food supplementation with coconut oil can cause obesity, study shows

< Ventura et al 2014 - Neurobiologic basis of craving for carbohydrates.

Verdon et al 2003 - Iron supplementation for unexplained fatigue in non-anaemic women: a controlled trial. >

Alcohol: What Women Need to Know - BOOK HERE

Supplementation with CO induces lipogenesis in adipose tissue, leptin and insulin resistance in healthy Swiss mice

Abstract:

FAB RESEARCH COMMENT:

Newsletter Signup

Useful Links

Contact Us

Important Notice